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When analyzing fetal defect incidence in laboratory animal studies, correlation in responses within litters (i.e., litter effects) can lead to increased false‐positive rates if litter effects are not incorporated into… Click to show full abstract
When analyzing fetal defect incidence in laboratory animal studies, correlation in responses within litters (i.e., litter effects) can lead to increased false‐positive rates if litter effects are not incorporated into the analysis. Studies of fetal defects require analysis methods that are robust across a broad range of defect types, including those with zero or near‐zero incidence rates in control groups.
Keywords:
analysis incidence;
incidence;
fetal defect;
incidence data;
litter effects
Journal Title: Birth Defects Research
Year Published: 2022
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Journal Title: Birth Defects Research
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!