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Association of prepregnancy body mass index and gestational weight gain on severity of optic nerve hypoplasia

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Optic nerve hypoplasia (ONH) is a birth defect of unknown etiology and a leading cause of visual impairment in developed countries. Recent studies suggest that factors of deprivation and exposures… Click to show full abstract

Optic nerve hypoplasia (ONH) is a birth defect of unknown etiology and a leading cause of visual impairment in developed countries. Recent studies suggest that factors of deprivation and exposures of poor nutritional status, such as lower gestational weight gain (GWG), may be associated with increased risk of ONH. The present study describes the prenatal features of mothers of ONH cases, including prepregnancy BMI and GWG, and the associations with clinical features of disease severity.

Keywords: gestational weight; optic nerve; nerve hypoplasia; weight gain

Journal Title: Birth Defects Research
Year Published: 2023

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