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Effects of ketamine‐induced H3K9 hypoacetylation during pregnancy on cardiogenesis of mouse offspring

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Prenatal exposure to adverse factors can cause congenital heart defects. Ketamine, a widely used anesthetic drug, produces several adverse reactions such as tachycardia, hypertension, and laryngospasm, especially in pediatric patients.… Click to show full abstract

Prenatal exposure to adverse factors can cause congenital heart defects. Ketamine, a widely used anesthetic drug, produces several adverse reactions such as tachycardia, hypertension, and laryngospasm, especially in pediatric patients. This study aimed to detect the effects of ketamine exposure during pregnancy on the cardiogenesis of mouse offspring and the potential mechanisms.

Keywords: cardiogenesis mouse; pregnancy cardiogenesis; effects ketamine; mouse offspring

Journal Title: Birth Defects Research
Year Published: 2023

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