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PDGFRα monoclonal antibody: Assessment of toxicity in juvenile mice administered a murine surrogate antibody of olaratumab

Olaratumab (Lartruvo™) is a recombinant human IgG1 monoclonal antibody that specifically binds PDGFRα. In order to support use of Lartruvo in pediatric patients, a definitive juvenile animal study in neonatal… Click to show full abstract

Olaratumab (Lartruvo™) is a recombinant human IgG1 monoclonal antibody that specifically binds PDGFRα. In order to support use of Lartruvo in pediatric patients, a definitive juvenile animal study in neonatal mice was conducted with a human anti‐mouse PDGFRα antibody analog of olaratumab (LSN3338786).

Keywords: pdgfr monoclonal; monoclonal antibody; antibody assessment; mice; juvenile; antibody

Journal Title: Birth Defects Research
Year Published: 2023

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