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Origins of life research: A roadmap for the transition from chemistry to biology

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The question of how life evolved from very simple molecules may be one of the biggest questions of mankind. This involves a deeper understanding of how interlocking reaction networks and… Click to show full abstract

The question of how life evolved from very simple molecules may be one of the biggest questions of mankind. This involves a deeper understanding of how interlocking reaction networks and chemical systemscanevolve.Theknowledgethatisobtainedwillprovideuswith answerstoquestionsaboutabiogenesis,howsimpleorganicmolecules evolved into complex biological systems, how these can be modi-fied by evolutionary mechanisms, and the general complexity required to trigger evolution at the molecular level. Small chemical systems that undergo self-driven synthesis, selection, and mutation, leading to selectivity and replication, are largely unknown. Whereas at the beginning of the emergence of life research the focus was on the synthesis of our well-known building blocks of life under prebiotic conditions, such as the assembly of nucle-osides and nucleotides or of amino acids and other com-pounds in the legendary Miller-Urey experiment, whole chemical systems are increasingly coming focus, showing the first steps of metabolism, the self-assembly of complex supramolecular structures tocellularstructuresorevenevolutionarybehavioratthe molecular level. study of structures and the bottom-up constructionofcellsasatransitionfromchemicaltobiologicalsystems within the of the func-tion of processes in for the of a for the origin of

Keywords: origins life; life research; chemistry; biology

Journal Title: BioEssays
Year Published: 2022

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