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Type VI secretion system (T6SS) is a contractile molecular syringe of gram-negative bacteria used to deliver toxins/effectors to the target prokaryotic or eukaryotic cells for antagonism or pathogenesis. This injection… Click to show full abstract
Type VI secretion system (T6SS) is a contractile molecular syringe of gram-negative bacteria used to deliver toxins/effectors to the target prokaryotic or eukaryotic cells for antagonism or pathogenesis. This injection system is composed of at least 13 structural components (TssA-M). The T6SS assembly process starts with the formation of the Tss(J)LM membrane complex (MC) followed by docking of the baseplate (BP) consisting of TssEFGK and VgrG-PAAR spike to the MC. Finally, the Hcp tube and TssBC sheath proteins start to polymerize on the BP. Upon TssBC sheath contraction, the Hcp-VgrG-PAAR-effector complex is propelled out of the cell for secretion or injecting effec-tors into the target cells. TssA is unique due to its key role in T6SS yet withdistinctdomainsincoordinatingHcp/TssBCtailpolymerizationby
Journal Title: BioEssays
Year Published: 2022
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