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Physiochemical properties of enveloped viruses and arginine dictate inactivation

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Therapeutic protein manufacturing would benefit by having an arsenal of ways to inactivate viruses. There have been many publications on the virus inactivation ability of arginine at pH 4.0, but… Click to show full abstract

Therapeutic protein manufacturing would benefit by having an arsenal of ways to inactivate viruses. There have been many publications on the virus inactivation ability of arginine at pH 4.0, but the mechanism of this inactivation is unknown. This study explored how virus structure and solution conditions enhance virus inactivation by arginine and leads to a better understanding of the mechanism of virus inactivation by arginine.

Keywords: virus inactivation; enveloped viruses; properties enveloped; physiochemical properties; inactivation; viruses arginine

Journal Title: Biotechnology Journal
Year Published: 2021

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