The area of biocatalysis has been experiencing tremendous growth from its early foundations to its present state of the art and science. Cross-inspiration and interconnections between the art and know-how… Click to show full abstract
The area of biocatalysis has been experiencing tremendous growth from its early foundations to its present state of the art and science. Cross-inspiration and interconnections between the art and know-how of different practical biocatalytic applications and the motivation for the creation of fundamental knowledge in the science of biocatalysis over time made problem-solving feasible to successfully and efficiently eliminate the associated bottlenecks. As building bridges across different cultures, disciplines, and interests has been a key success factor of past achievements, the current situation shows that this holds even more today. The current megatrends have intensified the need for providing system-relevant products, for considering resourceefficient and sustainable processes, and for providing resilient and robust supply chains. Boundary conditions such as resource limitations, safety, health, environment, and sustainability issues have become important drivers for innovation in science, industry, and society. Thereby, the science of biocatalysis is essential for creating new transformations and building new sustainable value chains on a global scale, although the focus is, on a different scale, addressing the molecular and engineering aspects of biocatalysis. Research, development, and innovation of biocatalysts in the form of whole cells, cell-free extracts, or isolated enzymes, their characterization, optimization, and engineering for desired transformation, as well as reaction and process engineering are key for enabling viable biocatalytic processes at scale. The
               
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