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Tyrosine sulfation is a post‐translational modification found on many surface receptors and plays an important role in cell‐cell and cell‐matrix interactions. However, tyrosine sulfation of therapeutic antibodies has only been… Click to show full abstract
Tyrosine sulfation is a post‐translational modification found on many surface receptors and plays an important role in cell‐cell and cell‐matrix interactions. However, tyrosine sulfation of therapeutic antibodies has only been reported very recently. Because of potential potency and immunogenicity concerns, tyrosine sulfation needs to be controlled during the manufacturing process.
Keywords:
tyrosine sulfation;
modulating tyrosine;
sulfation;
recombinant antibodies;
antibodies cho;
sulfation recombinant
Journal Title: Biotechnology Journal
Year Published: 2021
Link to full text (if available)
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Journal Title: Biotechnology Journal
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!