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Single‐cell RNA sequencing (scRNA‐seq) is a powerful method utilising transcriptomic data for detailed characterisation of heterogeneous cell populations. The use of oligonucleotide‐labelled antibodies for targeted proteomics addresses the shortcomings of… Click to show full abstract
Single‐cell RNA sequencing (scRNA‐seq) is a powerful method utilising transcriptomic data for detailed characterisation of heterogeneous cell populations. The use of oligonucleotide‐labelled antibodies for targeted proteomics addresses the shortcomings of the scRNA‐seq‐only based approach by improving detection of low expressing targets. However, optimisation of large antibody panels is challenging and depends on the availability of co‐functioning oligonucleotide‐labelled antibodies.
Journal Title: Biotechnology Journal
Year Published: 2022
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