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Advancing Raman model calibration for perfusion bioprocesses using spiked harvest libraries

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Raman spectroscopy has gained popularity to monitor multiple process indicators simultaneously in biopharmaceutical processes. However, robust and specific model calibration remains a challenge due to insufficient analyte variability to train… Click to show full abstract

Raman spectroscopy has gained popularity to monitor multiple process indicators simultaneously in biopharmaceutical processes. However, robust and specific model calibration remains a challenge due to insufficient analyte variability to train the models and high cross‐correlation of various media components and artifacts throughout the process.

Keywords: advancing raman; calibration perfusion; model calibration; model; raman model

Journal Title: Biotechnology Journal
Year Published: 2022

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