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Bone morphogenetic protein‐2 (BMP‐2) and transforming growth factor‐β1 (TGF‐β1) reportedly induce the osteogenic and tenogenic differentiation of anterior cruciate ligament (ACL)‐derived stem cells (LDSCs), respectively. However, few studies have investigated… Click to show full abstract
Bone morphogenetic protein‐2 (BMP‐2) and transforming growth factor‐β1 (TGF‐β1) reportedly induce the osteogenic and tenogenic differentiation of anterior cruciate ligament (ACL)‐derived stem cells (LDSCs), respectively. However, few studies have investigated the effect of BMP‐2/TGF‐β1 on the differentiation of LDSC. We developed a BMP‐2/TGF‐β1 gene insertion into an LDSC cell sheet that promotes tendon–bone healing in a mouse ACL reconstruction (ACLR) model.
Journal Title: Biotechnology Journal
Year Published: 2023
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