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Autologous fat transplantation alters gene expression patterns related to inflammation and hypoxia in the irradiated human breast

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Radiation‐induced fibrosis, an adverse effect of breast cancer treatment, is associated with functional and cosmetic impairment as well as surgical complications. Clinical reports suggest improvement following autologous fat transplantation, but… Click to show full abstract

Radiation‐induced fibrosis, an adverse effect of breast cancer treatment, is associated with functional and cosmetic impairment as well as surgical complications. Clinical reports suggest improvement following autologous fat transplantation, but the mechanisms underlying this effect are unknown. A global gene expression analysis was undertaken to identify genetic pathways dysregulated by radiation and evaluate the impact of autologous fat transplantation on gene expression.

Keywords: autologous fat; fat transplantation; gene expression

Journal Title: British Journal of Surgery
Year Published: 2019

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