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DJ‐1 mutation is a causative reason for familial Parkinson's disease (PD). Leucine166Proline (L166P) and C106S are two important DJ‐1 mutations. In this study, we established hydrogen peroxide (H2O2) induced L166P… Click to show full abstract
DJ‐1 mutation is a causative reason for familial Parkinson's disease (PD). Leucine166Proline (L166P) and C106S are two important DJ‐1 mutations. In this study, we established hydrogen peroxide (H2O2) induced L166P and C106S DJ‐1‐transfected neuroblastoma (SH‐SY5Y) cellular models of PD and investigated the effects of Cistanche extracts and key bioactive compounds, including acteoside, echinacoside, caffeic acid, and Cistanche total glycosides on these two models.
Keywords:
cistanche extracts;
hydrogen peroxide;
cellular models;
extracts ameliorates;
transfected neuroblastoma
Journal Title: Brain and Behavior
Year Published: 2019
Link to full text (if available)
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Journal Title: Brain and Behavior
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!