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Chronic nicotine exposure attenuates the effects of Δ9‐tetrahydrocannabinol on anxiety‐related behavior and social interaction in adult male and female rats

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Anxiogenic and anxiolytic effects of cannabinoids are mediated by different mechanisms, including neural signaling via cannabinoid receptors (CBRs) and nicotinic cholinergic receptors (nAChRs). This study examined the effects of prior… Click to show full abstract

Anxiogenic and anxiolytic effects of cannabinoids are mediated by different mechanisms, including neural signaling via cannabinoid receptors (CBRs) and nicotinic cholinergic receptors (nAChRs). This study examined the effects of prior nicotine (the psychoactive component in tobacco) exposure on behavioral sensitivity to delta‐9‐tetrahydrocannabinol (THC; the psychoactive component of cannabis) challenge in animals.

Keywords: exposure attenuates; effects tetrahydrocannabinol; nicotine exposure; chronic nicotine; exposure; attenuates effects

Journal Title: Brain and Behavior
Year Published: 2019

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