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Berberine enhances L1 expression and axonal remyelination in rats after brachial plexus root avulsion

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Enhanced remyelination of the regenerated axons results in functional re‐innervation and improved functional motor recovery after brachial plexus root avulsion (BPRA). The neural cell adhesion molecule L1 (L1CAM, L1) regulates… Click to show full abstract

Enhanced remyelination of the regenerated axons results in functional re‐innervation and improved functional motor recovery after brachial plexus root avulsion (BPRA). The neural cell adhesion molecule L1 (L1CAM, L1) regulates myelination and promotes regeneration after acute injury in the nervous system. Berberine (BBR) can exert neuroprotective roles against the lesion. Herein, we investigated whether berberine (BBR) can affect the expression of L1 and enhance the axonal remyelination in rats following BPRA.

Keywords: root avulsion; remyelination; axonal remyelination; plexus root; brachial plexus; berberine

Journal Title: Brain and Behavior
Year Published: 2020

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