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Collagen‐rich deposit formation in the sciatic nerve after injury and surgical repair: A study of collagen‐producing cells in a rabbit model

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Posttraumatic scarring of peripheral nerves produces unwanted adhesions that block axonal growth. In the context of surgical nerve repair, the organization of the scar tissue adjacent to conduits used to… Click to show full abstract

Posttraumatic scarring of peripheral nerves produces unwanted adhesions that block axonal growth. In the context of surgical nerve repair, the organization of the scar tissue adjacent to conduits used to span the gap between the stumps of transected nerves is poorly understood. The goal of this study was to elucidate the patterns of distribution of collagen‐rich scar tissue and analyze the spatial organization of cells that produce fibrotic deposits around and within the conduit's lumen.

Keywords: collagen; collagen rich; study; rich deposit; nerve; repair

Journal Title: Brain and Behavior
Year Published: 2020

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