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Disruption of copper homeostasis and dysfunction of mitochondria have been documented in sclerotic hippocampi (HS) of patients with mesial temporal lobe epilepsy (mTLE). However, a potential link between these pathological… Click to show full abstract
Disruption of copper homeostasis and dysfunction of mitochondria have been documented in sclerotic hippocampi (HS) of patients with mesial temporal lobe epilepsy (mTLE). However, a potential link between these pathological changes has not been tackled so far. Herein, we analyzed regional distribution of neuron somata density, copper concentration, and the activity of cytochrome c oxidase (CCO), a component of mitochondrial electron transport chain and copper‐containing metalloprotein, in HS.
Keywords:
epilepsy;
cytochrome oxidase;
copper;
regional distribution;
sclerotic hippocampi
Journal Title: Brain and Behavior
Year Published: 2020
Link to full text (if available)
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Journal Title: Brain and Behavior
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!