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Phenotypic characterization of frontal cortex microglia in a rat model of post‐traumatic stress disorder

Post‐traumatic stress disorder (PTSD) is an anxiety disorder induced by psychologically traumatic events. Using a rat model, this study aimed to determine whether psychological trauma alters relative expression between pro‐inflammatory… Click to show full abstract

Post‐traumatic stress disorder (PTSD) is an anxiety disorder induced by psychologically traumatic events. Using a rat model, this study aimed to determine whether psychological trauma alters relative expression between pro‐inflammatory and anti‐inflammatory markers in microglia. To meet this goal, expression of genes encoding i‐NOS, arginase, TNF‐α, interleukin‐10, CD74, and Mannose Receptor C was analyzed on multiple days following trauma exposure.

Keywords: post traumatic; stress disorder; disorder; traumatic stress; rat model

Journal Title: Brain and Behavior
Year Published: 2021

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