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Altered hippocampal volume and functional connectivity in patients with Cushing's disease

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Stress‐related brain disorders can be associated with glucocorticoid disturbance and hippocampal alteration. However, it remains largely unknown how cortisol affects the structure and function of hippocampus. Cushing's disease (CD) provides… Click to show full abstract

Stress‐related brain disorders can be associated with glucocorticoid disturbance and hippocampal alteration. However, it remains largely unknown how cortisol affects the structure and function of hippocampus. Cushing's disease (CD) provides a unique “hyperexpression model” to explore the effects of excessive cortisol on hippocampus as well as the relation between these effects and neuropsychological deficits.

Keywords: disease; hippocampal volume; volume functional; functional connectivity; altered hippocampal; cushing disease

Journal Title: Brain and Behavior
Year Published: 2022

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