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Ascorbic acid can alleviate the degradation of levodopa and carbidopa induced by magnesium oxide

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Levodopa and carbidopa are reported to be degraded by magnesium oxide (MgO), which is often used as a laxative for patients with Parkinson's disease (PD). Ascorbic acid (AsA) can stabilize… Click to show full abstract

Levodopa and carbidopa are reported to be degraded by magnesium oxide (MgO), which is often used as a laxative for patients with Parkinson's disease (PD). Ascorbic acid (AsA) can stabilize levodopa and carbidopa solutions; however, the effect of AsA on the degradation of levodopa and carbidopa induced by MgO has not been fully investigated.

Keywords: levodopa carbidopa; degradation levodopa; ascorbic acid; magnesium oxide; carbidopa

Journal Title: Brain and Behavior
Year Published: 2022

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