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Role of SNAP‐25 MnlI variant in impaired working memory and brain functions in attention deficit/hyperactivity disorder

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Attention deficit/hyperactivity disorder (ADHD) is a hereditary neurodevelopmental disorder characterized by working memory (WM) deficits. The MnlI variant (rs3746544) of the synaptosomal‐associated protein 25 (SNAP‐25) gene is associated with ADHD.… Click to show full abstract

Attention deficit/hyperactivity disorder (ADHD) is a hereditary neurodevelopmental disorder characterized by working memory (WM) deficits. The MnlI variant (rs3746544) of the synaptosomal‐associated protein 25 (SNAP‐25) gene is associated with ADHD. In this study, we investigated the role and underlying mechanism of SNAP‐25 MnlI variant in cognitive impairment and brain functions in boys with ADHD.

Keywords: hyperactivity disorder; attention deficit; mnli variant; brain; disorder; deficit hyperactivity

Journal Title: Brain and Behavior
Year Published: 2022

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