Studies have recognized that the loss of the blood–brain barrier (BBB) integrity is a major structural biomarker where neurodegenerative disease potentially begins. Using a combination of high‐quality neuroimaging techniques, we… Click to show full abstract
Studies have recognized that the loss of the blood–brain barrier (BBB) integrity is a major structural biomarker where neurodegenerative disease potentially begins. Using a combination of high‐quality neuroimaging techniques, we investigated potential subtle differences in BBB permeability in mid‐age healthy people, comparing carriers of the apolipoprotein E epsilon‐4 (APOEε4) genotype, the biggest risk factor for late onset, non‐familial AD (LOAD) with APOEε3 carriers, the population norm.
Journal Title: Brain and Behavior
Year Published: 2022
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