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Mapping Genetic Associations With Functional Brain Area Alterations in Schizophrenia and Implications for Cortical Development

While prior studies have identified regional reduction in gray matter (GM) volume in schizophrenia, it remains unclear whether these alterations are concentrated in specific brain functional areas and how they… Click to show full abstract

While prior studies have identified regional reduction in gray matter (GM) volume in schizophrenia, it remains unclear whether these alterations are concentrated in specific brain functional areas and how they relate to genetic factors. This study aimed to identify Brodmann's areas (BAs) with affected GM volume in individuals with schizophrenia, explore associated genetic variants through a genome‐wide association study (GWAS), and investigate the potential roles of these genes during cortical development.

Keywords: associations functional; brain; genetic associations; cortical development; mapping genetic

Journal Title: Brain and Behavior
Year Published: 2025

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