Tinnitus is a common condition where a person perceives sound despite there being no external auditory stimuli. It is proven that overexpression of NMDA (N‐methyl‐d‐aspartate) glutamate receptors increases the sensitivity… Click to show full abstract
Tinnitus is a common condition where a person perceives sound despite there being no external auditory stimuli. It is proven that overexpression of NMDA (N‐methyl‐d‐aspartate) glutamate receptors increases the sensitivity of neurons to glutamate transmission, creating a destructive cycle of excitotoxicity. NMDA receptor antagonists, such as memantine, seem to be effective in treating tinnitus. This study aimed to examine the effectiveness of memantine as a treatment for tinnitus in a double‐blind randomized placebo control clinical trial.
Journal Title: Brain and Behavior
Year Published: 2025
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