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Ameliorative Effects of High‐Intensity Interval Training (HIIT) and Methylphenidate Against Tramadol‐Induced Cognitive Impairment: The Role of Hippocampal Oxidative Stress

Tramadol (TM) abuse results in significant cognitive dysfunction. This study aimed to investigate the impact of an 8‐week high‐intensity interval training (HIIT) regimen and methylphenidate (MPH) administration (alone and in… Click to show full abstract

Tramadol (TM) abuse results in significant cognitive dysfunction. This study aimed to investigate the impact of an 8‐week high‐intensity interval training (HIIT) regimen and methylphenidate (MPH) administration (alone and in combination) on cognitive function and hippocampal oxidative stress markers following chronic TM administration.

Keywords: interval training; intensity interval; oxidative stress; training hiit; hippocampal oxidative; high intensity

Journal Title: Brain and Behavior
Year Published: 2025

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