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Adult newborn neurons interfere with fear discrimination in a protocol‐dependent manner

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Significant enhancement of neurogenesis is known to occur in response to a variety of brain insults such as traumatic brain injury. Previous studies have demonstrated that injury‐induced newborn neurons are… Click to show full abstract

Significant enhancement of neurogenesis is known to occur in response to a variety of brain insults such as traumatic brain injury. Previous studies have demonstrated that injury‐induced newborn neurons are required for hippocampus‐dependent spatial learning and memory tasks like the Morris water maze, but not in contextual fear conditioning that requires both the hippocampus and amygdala. Recently, the dentate gyrus, where adult hippocampal neurogenesis occurs, has been implicated in processing information to form specific memory under specific environmental stimuli in a process known as pattern separation.

Keywords: interfere fear; fear discrimination; adult; adult newborn; newborn neurons; neurons interfere

Journal Title: Brain and Behavior
Year Published: 2017

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