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Mitochondrial transcription factor A plays opposite roles in the initiation and progression of colitis‐associated cancer

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Mitochondria are key regulators in cell proliferation and apoptosis. Alterations in mitochondrial function are closely associated with inflammation and tumorigenesis. This study aimed to investigate whether mitochondrial transcription factor A… Click to show full abstract

Mitochondria are key regulators in cell proliferation and apoptosis. Alterations in mitochondrial function are closely associated with inflammation and tumorigenesis. This study aimed to investigate whether mitochondrial transcription factor A (TFAM), a key regulator of mitochondrial DNA transcription and replication, is involved in the initiation and progression of colitis‐associated cancer (CAC).

Keywords: transcription; initiation progression; mitochondrial transcription; transcription factor; cancer; progression colitis

Journal Title: Cancer Communications
Year Published: 2021

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