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Commentary: Addressing the Replication and Translation Crises Taking One Step Forward, Two Steps Back? A Plea for Slow Experimental Research Instead of Fast "Participatory" Studies.

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Randomized controlled trials are a special case of designs using an unbiased instrument to take care of confounders even if they are unmeasured or unknown. Another example of studies using… Click to show full abstract

Randomized controlled trials are a special case of designs using an unbiased instrument to take care of confounders even if they are unmeasured or unknown. Another example of studies using instrumental variables is the Mendelian experiment and Directed Acyclic Graphs show the power of such designs to enhance the internal validity. It is argued that internal validity is a necessary condition of ethically sound application of research findings in (clinical) practice and policy. Internal validity can only gradually and slowly be approximated through a spiraling process of ever more exact and varied replications, secondary analyses, meta-analyses, and umbrella reviews. This advocacy of slow science argues for distinct roles and responsibilities of practitioners and researchers in translational research.

Keywords: addressing replication; commentary addressing; internal validity; translation crises; replication translation; research

Journal Title: New Directions for Child and Adolescent Development
Year Published: 2019

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