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Effects of RhoC downregulation on the angiogenesis characteristics of myeloma vascular endothelial cells

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Tumor angiogenesis plays an important role in disease progression, and RhoC has been previously found to be expressed in vascular endothelial cells (VECs); however, its role in tumor angiogenesis requires… Click to show full abstract

Tumor angiogenesis plays an important role in disease progression, and RhoC has been previously found to be expressed in vascular endothelial cells (VECs); however, its role in tumor angiogenesis requires clarification. This study aimed to explore the effects of RhoC downregulation on the cytoskeleton, pseudopod formation, migration ability, and canalization capacity of myeloma vascular endothelial cells (MVECs) in vitro.

Keywords: angiogenesis; rhoc downregulation; vascular endothelial; endothelial cells; myeloma vascular; effects rhoc

Journal Title: Cancer Medicine
Year Published: 2019

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