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Genetic variants in p53 signaling pathway genes predict chemotherapy efficacy in colorectal cancer

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The murine double minute‐2 gene (MDM2) was originally identified as predicting chemotherapy efficacy. However, little is known regarding the association between single nucleotide polymorphisms (SNPs) in the p53 signaling pathway… Click to show full abstract

The murine double minute‐2 gene (MDM2) was originally identified as predicting chemotherapy efficacy. However, little is known regarding the association between single nucleotide polymorphisms (SNPs) in the p53 signaling pathway and prognosis/chemotherapy sensitivity in colorectal cancer.

Keywords: chemotherapy; p53 signaling; colorectal cancer; signaling pathway; cancer; chemotherapy efficacy

Journal Title: Cancer Medicine
Year Published: 2019

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