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Smad4 and p53 synergize in suppressing autochthonous intestinal cancer

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Smad4 and p53 mutations are the most common mutations in human colorectal cancers (CRCs). We evaluated whether and how they are synergistic in intestinal carcinogenesis using novel autochthonous mouse models. Click to show full abstract

Smad4 and p53 mutations are the most common mutations in human colorectal cancers (CRCs). We evaluated whether and how they are synergistic in intestinal carcinogenesis using novel autochthonous mouse models.

Keywords: smad4 p53; synergize suppressing; p53 synergize; smad4; cancer

Journal Title: Cancer Medicine
Year Published: 2022

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