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Changes in adiposity over the life course and gene expression in postmenopausal women

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Early life adiposity and changes in adiposity over the life course are associated with mammographic breast density among postmenopausal women. However, the underlying mechanisms are unknown; therefore, we comprehensively examined… Click to show full abstract

Early life adiposity and changes in adiposity over the life course are associated with mammographic breast density among postmenopausal women. However, the underlying mechanisms are unknown; therefore, we comprehensively examined the associations of early life body mass index (BMI) and changes in BMI from ages 10, 18 to age at mammogram with growth factor, RANK pathway, and sex hormone gene expression in 372 postmenopausal women.

Keywords: adiposity life; changes adiposity; life; life course; gene expression; postmenopausal women

Journal Title: Cancer Medicine
Year Published: 2022

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