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SPP1 promotes radiation resistance through JAK2/STAT3 pathway in esophageal carcinoma

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Therapeutic resistance to radiotherapy is one of the major obstacles in clinical practice that significantly affect the therapeutic efficiency and prognosis of human esophageal carcinoma (ESCA). Thus, it is critical… Click to show full abstract

Therapeutic resistance to radiotherapy is one of the major obstacles in clinical practice that significantly affect the therapeutic efficiency and prognosis of human esophageal carcinoma (ESCA). Thus, it is critical to understand the molecular mechanisms of radiation resistance in ESCA. Secreted phosphoprotein 1 (SPP1) plays an essential role in various human cancers, but its role in radiation resistance remains unclear.

Keywords: esophageal carcinoma; resistance; radiation resistance; spp1

Journal Title: Cancer Medicine
Year Published: 2022

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