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Characterization of rare histological subtypes of ovarian cancer based on molecular profiling

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Pan‐cancer analysis across The Cancer Genome Atlas has revealed the molecular profiles of major types of carcinomas. High‐grade serous carcinomas (HGSCs) have been characterized; however, in ovarian cancer, the profile… Click to show full abstract

Pan‐cancer analysis across The Cancer Genome Atlas has revealed the molecular profiles of major types of carcinomas. High‐grade serous carcinomas (HGSCs) have been characterized; however, in ovarian cancer, the profile of carcinoma with minor histopathological changes remains unclear. This study aimed to perform the molecular profiling of rare malignant ovarian tumors, including non‐epithelial tumors (NETs; germ cell tumors and sex cord tumors) and clear cell carcinoma (CCC), to determine how they differ from the major HGSCs.

Keywords: ovarian cancer; rare histological; characterization rare; histological subtypes; molecular profiling; cancer

Journal Title: Cancer Medicine
Year Published: 2022

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