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Integrative metabolomics and transcriptomics analysis reveals novel therapeutic vulnerabilities in lung cancer

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Non‐small cell lung cancer (NSCLC) comprises the majority (~85%) of all lung tumors, with lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) being the most frequently diagnosed histological subtypes. Multi‐modal… Click to show full abstract

Non‐small cell lung cancer (NSCLC) comprises the majority (~85%) of all lung tumors, with lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) being the most frequently diagnosed histological subtypes. Multi‐modal omics profiling has been carried out in NSCLC, but no studies have yet reported a unique metabolite‐related gene signature and altered metabolic pathways associated with LUAD and LUSC.

Keywords: lung cancer; metabolomics transcriptomics; transcriptomics analysis; integrative metabolomics; analysis reveals; cancer

Journal Title: Cancer Medicine
Year Published: 2022

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