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Drug library screening identifies histone deacetylase inhibition as a novel therapeutic strategy for choriocarcinoma

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Choriocarcinoma is a rare and aggressive gynecological malignancy. The standard treatment is systemic chemotherapy as choriocarcinoma exhibits high chemosensitivity. However, refractory choriocarcinoma exhibits chemoresistance; thus, the prognosis remains very poor.… Click to show full abstract

Choriocarcinoma is a rare and aggressive gynecological malignancy. The standard treatment is systemic chemotherapy as choriocarcinoma exhibits high chemosensitivity. However, refractory choriocarcinoma exhibits chemoresistance; thus, the prognosis remains very poor. This study aimed to identify novel therapeutic agents for choriocarcinoma by utilizing a drug repositioning strategy.

Keywords: choriocarcinoma; drug library; novel therapeutic; library screening; strategy

Journal Title: Cancer Medicine
Year Published: 2022

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