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DNA‐dependent protein kinase (DNA‐PK) is engaged in DNA damage repair and is significantly expressed in triple negative breast cancer (TNBC). Inhibiting DNA‐PK to reduce DNA damage repair provides a possibility… Click to show full abstract
DNA‐dependent protein kinase (DNA‐PK) is engaged in DNA damage repair and is significantly expressed in triple negative breast cancer (TNBC). Inhibiting DNA‐PK to reduce DNA damage repair provides a possibility of tumor treatment. NU7441, a DNA‐PK inhibitor, can regulate the function and differentiation of CD4+T cells and effectively enhance immunogenicity of monocyte‐derived dendritic cells. However, the effect of NU7441 on the tumor progression activity of immunosuppressive myeloid‐derived suppressor cells (MDSCs) in TNBC remains unclear.
Journal Title: Cancer Medicine
Year Published: 2022
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