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Evolution of lung adenocarcinoma from preneoplasia to invasive adenocarcinoma

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Mutations in driver genes contribute to the development and progression of lung adenocarcinoma (LUAD). However, in the dynamic evolutionary process from adenocarcinoma in situ (AIS) to minimally invasive adenocarcinoma (MIA)… Click to show full abstract

Mutations in driver genes contribute to the development and progression of lung adenocarcinoma (LUAD). However, in the dynamic evolutionary process from adenocarcinoma in situ (AIS) to minimally invasive adenocarcinoma (MIA) and eventually to invasive adenocarcinoma (IAC), the role of driver genes is currently unclear. This study aimed to analyse the role of driver gene status in the progression of LUAD from preneoplasia to IAC.

Keywords: lung adenocarcinoma; invasive adenocarcinoma; evolution lung; preneoplasia; adenocarcinoma

Journal Title: Cancer Medicine
Year Published: 2022

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