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RNA‐seq and ATAC‐seq analysis of CD163 + macrophage‐induced progestin‐insensitive endometrial cancer cells

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Progestins are used as fertility‐sparing regimens for young patients with stage 1A endometrioid endometrial cancer (EEC) and atypical endometrial hyperplasia (AEH). CD163+ macrophages promote estrogen‐dependent EEC development, but whether they… Click to show full abstract

Progestins are used as fertility‐sparing regimens for young patients with stage 1A endometrioid endometrial cancer (EEC) and atypical endometrial hyperplasia (AEH). CD163+ macrophages promote estrogen‐dependent EEC development, but whether they induce progestin insensitivity remains unclear. This study aimed to investigate the possible effects of CD163+ macrophages on progestin response in AEH/EEC patients.

Keywords: endometrial cancer; rna seq; cd163; seq atac; cancer

Journal Title: Cancer Medicine
Year Published: 2022

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