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An innovative single‐base extension method for synchronous detection of point mutations and MSI status in colorectal cancer

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An accurate genotyping analysis is one of the critical prerequisites for patients with colorectal cancer receiving matched therapies. Conventional genotyping analysis is currently used to detect either gene mutations or… Click to show full abstract

An accurate genotyping analysis is one of the critical prerequisites for patients with colorectal cancer receiving matched therapies. Conventional genotyping analysis is currently used to detect either gene mutations or MSI status, delaying the detection of critical tumor biomarkers and thus the optimal time for treatment. An assay that analyzes both biomarkers in a streamlined process is eagerly needed.

Keywords: msi status; detection; colorectal cancer; mutations msi; cancer

Journal Title: Cancer Medicine
Year Published: 2022

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