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Matching‐adjusted indirect comparison of isatuximab plus carfilzomib and dexamethasone with daratumumab plus lenalidomide and dexamethasone in relapsed multiple myeloma

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Lenalidomide‐based regimens are commonly used for early relapse in patients with relapsed and/or refractory multiple myeloma (RRMM) receiving at least one prior line of therapy. In the absence of head‐to‐head… Click to show full abstract

Lenalidomide‐based regimens are commonly used for early relapse in patients with relapsed and/or refractory multiple myeloma (RRMM) receiving at least one prior line of therapy. In the absence of head‐to‐head comparison, matching‐adjusted indirect comparison (MAIC) was conducted to demonstrate efficacy and safety of isatuximab+carfilzomib+dexamethasone (Isa‐Kd) versus daratumumab + lenalidomide + dexamethasone (Dara‐Rd) in RRMM.

Keywords: matching adjusted; indirect comparison; comparison; adjusted indirect; multiple myeloma; dexamethasone

Journal Title: Cancer Medicine
Year Published: 2023

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