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Par14 interacts with the androgen receptor, augmenting both its transcriptional activity and prostate cancer proliferation

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Prostate cancer (PCa) is a major cause of cancer morbidity and mortality for men globally, and androgen signaling clearly drives its onset and progression. Androgen receptor (AR) regulation is complex… Click to show full abstract

Prostate cancer (PCa) is a major cause of cancer morbidity and mortality for men globally, and androgen signaling clearly drives its onset and progression. Androgen receptor (AR) regulation is complex and remains elusive, despite several studies tackling these issues. Therefore, elucidating the mechanism(s) underlying AR regulation is a potentially promising approach to suppressing PCa.

Keywords: par14 interacts; androgen receptor; prostate cancer; cancer

Journal Title: Cancer Medicine
Year Published: 2022

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