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Prognostic analysis of three forms of Ki‐67 in patients with breast cancer with non‐pathological complete response before and after neoadjuvant systemic treatment

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Patients who do not achieve a pathological complete response (pCR) after neoadjuvant systemic treatment (NST) have a significantly worse prognosis. A reliable predictor of prognosis is required to further subdivide… Click to show full abstract

Patients who do not achieve a pathological complete response (pCR) after neoadjuvant systemic treatment (NST) have a significantly worse prognosis. A reliable predictor of prognosis is required to further subdivide non‐pCR patients. To date, the prognostic role in terms of disease‐free survival (DFS) between the terminal index of Ki‐67 after surgery (Ki‐67T) and the combination of the baseline Ki‐67 at biopsy before NST (Ki‐67B) and the percentage change in Ki‐67 before and after NST (Ki‐67C) has not been compared.

Keywords: complete response; neoadjuvant systemic; systemic treatment; pathological complete

Journal Title: Cancer Medicine
Year Published: 2023

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