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Prevalence of pathogenic variants in cancer-predisposing genes in second cancer after childhood solid cancers.

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Second malignant neoplasms (SMNs) are one of the most severe late complications after pediatric cancer treatment. However, the effect of genetic variation on SMNs remains unclear. In this study, we… Click to show full abstract

Second malignant neoplasms (SMNs) are one of the most severe late complications after pediatric cancer treatment. However, the effect of genetic variation on SMNs remains unclear. In this study, we revealed germline genetic factors that contribute to the development of SMNs after treatment of pediatric solid tumors.

Keywords: pathogenic variants; prevalence pathogenic; variants cancer; cancer predisposing; predisposing genes; cancer

Journal Title: Cancer medicine
Year Published: 2023

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