CREB binding protein (CREBBP) is a key epigenetic regulator, altered in a fifth of relapsed cases of acute lymphoblastic leukemia (ALL). Selectively targeting epigenetic signaling may be an effective novel… Click to show full abstract
CREB binding protein (CREBBP) is a key epigenetic regulator, altered in a fifth of relapsed cases of acute lymphoblastic leukemia (ALL). Selectively targeting epigenetic signaling may be an effective novel therapeutic approach to overcome drug resistance. Anti‐tumor effects have previously been demonstrated for GSK‐J4, a selective H3K27 histone demethylase inhibitor, in several animal models of cancers.
Keywords:
resistance;
acute lymphoblastic;
lymphoblastic leukemia;
crebbp;
h3k27
Journal Title: Cancer Medicine
Year Published: 2025
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Journal Title: Cancer Medicine
Year Published: 2025
Link to full text (if available)
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recommendations!