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Early Tumor Shrinkage and Depth of Response as Predictive Markers of Treatment Response and Prognosis in Solid Tumors

Evaluation of tumor efficacy is central to cancer care. Progression‐free survival (PFS) is widely used as an early surrogate for treatment effectiveness, but more timely and reliable biomarkers are needed.… Click to show full abstract

Evaluation of tumor efficacy is central to cancer care. Progression‐free survival (PFS) is widely used as an early surrogate for treatment effectiveness, but more timely and reliable biomarkers are needed. Early tumor shrinkage (ETS) and depth of response (DpR) have emerged as promising predictors: ETS reflects early treatment sensitivity at first radiologic assessment, whereas DpR quantifies the maximum tumor reduction and may capture the durability of benefit.

Keywords: treatment; response; tumor shrinkage; depth response; tumor; early tumor

Journal Title: Cancer Medicine
Year Published: 2025

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