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Upregulation of the lncRNA SRLR in polycystic ovary syndrome regulates cell apoptosis and IL‐6 expression

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Increased levels of interleukin‐6 (IL‐6) contribute to the development of polycystic ovary syndrome (PCOS); in renal cell carcinoma, the long non‐coding RNA (lncRNA) SRLR upregulates IL‐6. In this study, we… Click to show full abstract

Increased levels of interleukin‐6 (IL‐6) contribute to the development of polycystic ovary syndrome (PCOS); in renal cell carcinoma, the long non‐coding RNA (lncRNA) SRLR upregulates IL‐6. In this study, we demonstrated that the levels of the lncRNA SRLR were upregulated in PCOS patients with high expression of plasma IL‐6 compared with heathy females. The levels of the lncRNA SRLR in the plasma had a positive correlation with expression of IL‐6 in patients with PCOS but not in healthy females. Upregulation of the lncRNA SRLR in plasma could distinguish PCOS patients from healthy females. Overexpression of the lncRNA SRLR led to upregulation of IL‐6 and promoted apoptosis of human granulosa‐like tumour cells (KGN). Therefore, the lncRNA SRLR participated in PCOS by regulating cell apoptosis and IL‐6 expression.

Keywords: polycystic ovary; lncrna srlr; cell apoptosis; ovary syndrome; expression; upregulation lncrna

Journal Title: Cell Biochemistry and Function
Year Published: 2020

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