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Computation‐Guided Design of a Stimulus‐Responsive Multienzyme Supramolecular Assembly

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The construction of stimulus-responsive supramolecular complexes of metabolic pathway enzymes, inspired by natural multienzyme assemblies (metabolons), provides an attractive avenue for efficient and spatiotemporally controllable one-pot biotransformations. We have constructed… Click to show full abstract

The construction of stimulus-responsive supramolecular complexes of metabolic pathway enzymes, inspired by natural multienzyme assemblies (metabolons), provides an attractive avenue for efficient and spatiotemporally controllable one-pot biotransformations. We have constructed a phosphorylation- and optically responsive metabolon for the biodegradation of the environmental pollutant 1,2,3-trichloropropane.

Keywords: stimulus; guided design; computation guided; multienzyme; supramolecular; stimulus responsive

Journal Title: ChemBioChem
Year Published: 2017

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