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RNA G‐quadruplex (G4)‐forming motifs present at the 5′‐UTR of the protein phosphatase (PP2Ac) gene are the regulatory targets of the fragile X mental retardation protein (FMRP), which is weakly expressed… Click to show full abstract
RNA G‐quadruplex (G4)‐forming motifs present at the 5′‐UTR of the protein phosphatase (PP2Ac) gene are the regulatory targets of the fragile X mental retardation protein (FMRP), which is weakly expressed in Fragile X patients. Herein, we report that the existence of such G4‐forming sequence represses the translation of the PP2Acα gene. This study opens therapeutic avenues to design small molecule ligands that mimic the function of the FMRP.
Keywords:
rna forming;
rna;
forming motifs;
quadruplex rna;
potential quadruplex;
presence potential
Journal Title: ChemBioChem
Year Published: 2019
Link to full text (if available)
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Journal Title: ChemBioChem
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!